It's 20freaking22 or whatever it is! We obviously know every protein that is involved in DNA damage repair!
This study makes a very good argument that...no...actually...no, we do not and here is a couple more!
They do some solid proteomics and then go back and do some even more solid molecular biology. Knockout these proteins and try that experiment again? These things are important!
Imagine you just got back from the printers the 3rd edition of your textbook you sent out for printing in 2019 and some bozos with a mass spectrometer totally screw up Chapter 4?!?