Distal tumor extracellular vesicles screw up liver metabolism!

There isn't any real proteomics in this, but my gosh, this is just a huge and inspirational study. 

There is some really good mass spec in it, but it's all metabolomics and lipidomics and a lot is done by GC-MS. The thing that really stands out in this study is how well orchestrated it seems to have been. With this many authors I guess you hope that is the case, but when you're bringing together a team using -- it must be 20 different technologies -- at least 7 cell lines, multiple mutations, etc., THEN purification of rare Kuppfer(?) cells from mice to test the hypothesis that you've got an active disease agent from a tumor WAAAAAY over here circulating in the blood and then activating a rare cell type in the liver?

Really drives home what you can do with a big team working well together and yet another big paper where the mass spectrometry is great, it's solid, it plays a pivotal role, but is isn't the star of the show - and it works.