AI in proteomics - from protein identification to virtual cells!

 

Man, I need to start being more collaborative so I can get on these gigantic papers that are going to get a billion lazy citations (that's where you use the title and abstract to make a citation without ever reading the paper).

This new one is definitely going to get cited like crazy and since there are people out there who judge you by how many citations you have, each of these people are going to get supercharged CVs! 

You don't have to read it, you can just guess what it's about and when you need a citation number 68 for deep learning you can just pop this one in. 

There are SO MANY obvious uses of AI out there! Check out this month's cover of the Journal of Proteome Research (real, not edited) - it's killing me. 

Wait. So....WHAT IS IN THE "S-TRAP?" It's a lava lamp shaped like a 1980s Bosch automobile fuel filter! AND the EvoTip loading is a syringe that drips Play-Doh(TM) onto the top of an oRsBiTraP? 

I posted this on the socials somewhere else, but it's similar to this used TIMMYTOOFY SCeePea system from Booker Caltronics. 

Objectively, $350k is pretty legit, but you do have to wonder why the decision was made to like not...take a picture of the system.... 

Proteome Discoverer 3.3 has a DIA-NN (commercial license required) node!

 

I was trying to help someone out who, due to the fact the US government is working great, has instruments but can't pay their annual license fee to use the DIA cloud nodes. I was like - how hard could it be to link PD through the node maker things to DIA-NN and then integrate the whole thing.

Up until the .parquet thing appears it looked pretty straight-forward if you're smart, but I'm not and it all looked like it was going to work, but wasn't so I decided to blame it on 1) whatever I was actually supposed to be doing 2) the parquet thing and 3) and the fact that after a certain version, DIA-NN isn't entirely open access. It's free but there are permissions to consider. Yeah, that's totally what it was. One or all of those. 

Turns out there is already a DIA-NN node released in 2026. That was last year? Nope! This year! It's still 2026!

You can watch a webinar about it here by the amazing Michaela Scigelova and that DIA-NN guy. 

Now...obviously...it only accepts .raw files. But why would you run anything else in Thermo's solution for Protein Informatics? Weirdo.