When I think of proximity extension assays (PEA) which is either famous because of O-Link - or is? O-Link, I think of purely using it for large population studies or for validating discoveries by high depth mass spectrometry based proteomics.
But...could you use it in place of mass spec proteomics? Because that is basically what this group did here.
Now...if your protein or proteoform isn't in this panel and that's all you see, you've just wasted a lot of money and time. However, in this case the depth afforded the serum proteomics allows the discovery of some interesting new proteins in a small cohort. Which then seems to be supported when they run a slightly larger pile of samples. So, in this case it looks like a win!
No comments:
Post a Comment