Mapping viral infection with imaging proteomics!

 

I'm no expert in imaging mass spectrometry (yet. I hope to get there since I've got two!) but I've been suprised/shocked by some of the limitations in the technology in 2022. This group of experts talk about these limitations in a refreshingly frank manner... 

...and how they try to work around them. 

This study is largely evidence that their current procedure of working exclusively with MS1 medium resolution TOF can differentiate viral peptides in a known model. I won't lie, it sounds like a pain in the butt with overlaying slices and multiple data types, but those images look awesome!