Separate single cells, extract metabolites and ionize them in one go!

 

I'm going to bore (boor? bour?) anyone unlucky enough to visit this awful blog because this study is on:

Single cells

AND 

Metabolomics

This is a 3D printed ionization source that allows you to put in a population of cells. Then the cells have to go in single file because they are being pushed down something too small for them to bunch up in.

While they are being pushed through the metabolites are extracted out of them!

THEN the metabolites are directly ionized into an Orbitrap (looks like a Classic!)

And...no joke, it actually looks like it works.

If you're following along in the statistics world, someone recently realized that there are problems with some of the advanced statistics used in single cells. We'll ignore it right now 'cause the dust may settle one day, but according to these plots, they can tell different cancer cells apart using this crazy source!