Saturday, March 16, 2024

Improve intact protein analysis with outlier rejection borrowed from astronomy!



Apparently mass spectrometers aren't the only thing that generate "spectra"! And we aren't the only people who have to worry about averaging lots of measurements because we have limited signal.

Would it be worth borrowing some tools from one of these other fields for -- a 45% increase in intact protein identifications?!?!? 


Considering how many people in our field will drop $1M for a 20% increase in IDs, I'd say this is worth taking a look at. And - you don't even have to - it looks like you can just upgrade MetaMorpheus and run some topdown proteomics through it (good benchmark dataset here) and just use the new "averaging with rejection" feature. 

 

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