Saturday, July 24, 2021

Isobaric tags alter phosphopeptide enrichment -- new method to fix it!

 In depressing news, this new study demonstrates that isobaric tagging reagents (at least the Tandem Mass Tags) cause problems with some common phosphopeptide enrichment strategies.

Fortunately, they point this out along with a super efficient way to get around it and prove it with ridiculously efficient recovery of phosphopeptides from 50 micrograms of treated human cell lysate! 

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