Were you at ASMS? If so, you probably remember seeing a ridiculous amount of amazing chemical crosslinked data like this!
All of it was based on a centralized workflow:
1) Better chemical crosslinker (DSSO!)
2) Optimized workflow to exploit the unique signature produced by said crosslinker in MS/MS
3) An easy, integrated data processing workflow designed specifically for processing it!
Orbitrap Fusion software 2.1 is out (and amazing!) and now you can buy the crosslinking reagent here!
Let's do some protein-protein interaction studies fo' real, yo! (Let me know if you need help processing the data, I'll try to help -- probably not even kidding.)
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