Sometimes you already know your targets, but porting them to a targeted assay is BORING, and typically requires one of those crappy triple quads. One transition per peptide? Repetitive and boring and you basically get a true/false for each transition per scan. Is it real? Is it coeluting in this one patient? Good luck sorting that out!
Could you use a super fast, crazy sensitive, but absolutely overpriced (come on, y'all, you've got the only ion trap, you could claim targeted proteomics market share) ion trap to get PRM (multiple transitions per target!) to biomarker studies?
Maybe! Wait. Maybe if someone proved it could work to the QQQ people then you could maybe then try to corner the targeted market?
This group went up to 300 SPD with almost 1,000 samples! 300SPD wasn't everything they hoped and dreamed, but the quan at 140 SPD looks great! That's still a 1,000 cohort study in a couple of days. Okay, it's several days, but still. I'm impressed. Now...if only the clinics could afford it.....
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