Wait. SDS-PAGE has enough sensitivity for single cell proteomics? Hmmmm.... It probably does....at least for high concentration band recognition...and it would provide some level of proteoform resolution.
I'll be honest, I first thought "...that sounds slow and silly..." but the more I think about it the more I like having this around as a concept - or even a first pass.
They use the migration patterns for their output and then use statistics that can tell different single cancer cells apart by those patterns....
I don't know about the 3D imaging part, and it is a preprint, so grain of salt over your shoulder or whatever, but I'm definitely going to think about this on my commute.
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