Okay! This is more of what proteomics needs! More sophisticated and better chromatography needs to sneak in here and there and this great note is a perfect example of why.
My heart sank when I realized a lot of people were breaking out the SCX columns to enrich for their crosslinked peptide species. I'm sure SCX still has uses out there in the world, but when I hear those letters all I think of is putting in milligrams of peptides and getting micrograms back, so maybe this is the answer?
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