APEX in situ proteomics is super cool stuff, and before everyone shut down or had to do COVID proteomics for 2 years, it looked like that was all anyone was uploading to ProteomeXchange.
(If you aren't familiar, here is something about APEX and it's friend Bio-ID I never did get sorted out entirely).
Why go to the trouble?
Name another technique that provides cell-type specific quantitative profiling of subcellular proteomics in the brain of a mammal. I'll wait. AND Worth checking out if only for the pretty pictures.