This is just a beautiful study to flip through if you're interested in doing chemoproteomics.
Sure, this isn't the first DIA chemoproteomics study that we've seen but -- and this could just be due to exposure and time to digest a previous study -- it somehow seems to be more approachable in this one.
Maybe it's that they don't have the strict page limits some other journals have? Or maybe it's that they use DIA on a Q Exactive Plus and use SpectroNaut? (All the methods are in the supplemental in this one.)
I'm not sure, but either way they do a great job of finding proteins that are drug targets with this method, so if this is of interest it's worth checking out.
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