Friday, January 7, 2022

TIMS Reduces coisolation interference! Hard numbers on how much.


FAIMS is super cool and I'm a big fan of the current iteration of the technology, but it's basically got a resolution of something like 5 or 10, right? It's superb for reducing background and that's what just about everyone uses it for, but if you set up 100 different compensation voltages and get an MS scan for each one of them, you've wasted a lot of time. A CV of 20 and 40 looks pretty different, but a 22 and a 24 look just about the same. Other ion mobility things have much higher resolution, but it's been tough to really quantify how much they help. 

Here two people who are really good at math work it all out! 

The reduction in coisolation interference is a lot. It's almost a 10x reduction compared to the TOF without TIMS! At the speed these things run at? That's ridiculously awesome -- reminder, you can realistically get 80+ high res scans/second on these things. Now, you do have to throw out the caveat that the quad is....umm....well, NASA can't build a quad this good, and neither can I, but you don't buy it for it's quadrupole isolation. 

Now, if you could only do multiplexed quantification on one of these things? Sounds like if you really thought about your TIMS isolation you could get some really really good numbers for coisolation interference! 

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