Monday, January 24, 2022

PRM-PASEF without fancy software!


PRM-PASEF was a big topic at the first remote ASMS and it totally worked, but you had to modify an SQLite file manually (how I was doing it) or with Skyline (which, in my hands caused PCs to struggle to load the huge DDA files to make targets). The software on these instruments is continuing to improve and the newest OTOF control (Compass 2022?) includes a PRM scheduling table like those on other instruments. Type in mass of peptide and it's ion mobility). 

How's it perform against traditional targeted approaches? (By "multiplexed" it isn't talking about TOMAHAQ type stuff.)

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