A Q Exactive UHMR (m/z range up to 80,000!) was modified a little bit so that native proteins could be cleaned up and deposited onto transmission electron microscopy grids for cryo electron microscopy!
So....the biggest challenge with Cryo-EM is often QC'ing your samples, to the point that people will buy a couple QE UHMRs just to save some time getting good proteins....but then they can embed poorly or crystalize poory and ruin everything. What if you cut all the middle right out? Crazy.