Saturday, April 24, 2021

Reversing stem cell state differentiation!

Warning: This is a stem cell paper. In order to read it you must get a spare sheet of paper on which to write all the acronyms and tape it to the side of your monitor. It's like reading an LCMS proteomics paper if you haven't been running your own system for 3 or more years. 

I don't get all the biology, of course, but I kind of get the gist of it. Primary cells in culture get old and you can't use them anymore. This group has a way to push the cells that they're interested in back into doing what they were originally doing before they got old. Super cool, right?!? I can draw all sorts of ignorant implications from this and I'll keep them to myself.

Okay, while it's cool to be able to do this, the next obvious question is: what is the responsible element(s)? Can you hunt it down and put it in a vial? 

Using a combination of RNASeq and proteomics (Q Exactive HF) they come up with a list of potential candidates. The RAW and processed files are up on ProteomeXchange at this identifier: PXD021069

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