Sunday, September 23, 2018

Proteome-Wide Structural biology -- Where are we now?

(Figure from Rual et al., Nature 2005)

It probably is no surprise to you that using proteomics for structural biology is growing like crazy right now. It seems like every day another one of our 250 or so researchers sees some data from someone else's DSSO protein crosslinking study we knocked out and is excited to send us samples. At this point I think the queue for our only Fusion is longer than most reasonable estimates for my life expectancy and DSSO might be the main reason.

But protein crosslinking is just one of many structural biology techniques that is benefiting from our massive improvements in instrument speed, resolution, sensitivity -- and, more importantly(maybe?) our access to alter our instrument experiment logic (seriously -- maybe above all else, the reason the Fusion is so powerful -- though MaxQuant Live may offset that somewhat when it launches).

Where does our field stand in 2018? This great update in this month's JPR has all the answers!

It goes into techniques you've probably heard of and maybe forgot years ago when it sounded smart, but the hardware just couldn't pull it off. Maybe it's time to revisit these with what we can do today! (Honestly, it has a bunch I swear I've never heard of at all -- and those are cool too!!)

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