I'm great Mr. Mouse, thank you for asking. So rather than share any annoyance about what I read over my lunch, we're going to remind people about these 10 year old findings!
Look, there are places for animal model data. There really are. Core metabolism is just like ours with few changes. However, if you're using mice as a neurological model and testing something that impacts higher level functioning in humans - using mice, which absolutely do not have the pathways in question - you're just being silly. I linked the editorial, because no one has to read much past the fact that 0 ALS drugs that worked in mice had any level of efficacy in humans.
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