THERMO BOUGHT O-Link - WTaF (actual fourier)??

 

So......in today's news.....antibody based quan is officially "next generation" proteomics technology. What is discarded is new again. 

On the up-side I bet we finally get to see some data pitting something we know is quantitatively accurate against O-link soon, if it works! If it doesn't, I bet we'll be able to tell from...well...if we don't see the data....

I'm not allowed to own stock in privately held biotechnology companies, but I sure wouldn't have thought O-link was gonna DogeCoin today.

If you are new to this blog, sorry, this is really a venting ground for a sarcastic first gen scientist with filter issues. 

Yes, O-link is an antibody based technology, and those are very very very well known to be error prone, poorly quantitative and to have immensely frustrating off-target effects and batch to batch variation.

O-link has a smart double hit QC thing that reduces false discovery rates. And the antibodies have a nucleotide sticking off of them. You amplify the antibody by PCR for the targeting stuff or use next gen sequencing (cause it's faster) for the other stuff. 

Still an antibody based assay that relies on the successful reproducible creation of something billions of years of evolution has imbued with the ability to be ...not...reproducible....but in a smarter/better way that the exact same sort of technology (this stuff has been around for 20 years) would have been done.

I'm DYING TO SEE SOME REAL HEAD TO HEAD DATA but that doesn't mean this stuff doesn't work. And I sure as hell would take their double hit antibody technology over any single hit protein microarray of the past.  

Data please. Data please. Data please. Data please.