If you promise not to break the server, I'll give you the link here!
WOOOOOOO! I've been dreaming about a program like this for years and I bet you have too.
I don't know if there is a paper yet. I clicked the wrong link and saw that this had moved from "coming soon" to live. And the manual references a paper (yo, if you need a reviewer, I'm only at 75 for the year so far)
Why am I super stoked about this one? Check out this option!!
I've rambled about this before, but for just about everything I do the phosphorylation information exists in two possibilities.
1) Protein level increases (but phospho-level remains the same). If you just phospho- enrich, who knows which one it is? Not you, that's for sure.
2) Protein level remains static but phosphorylation site occupancy increases.
I don't know why exactly, but to most people I know the amount of ERK vs phospho-ERK is a very important thing. So important, in fact, that they'll do western blots.
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