Tuesday, August 31, 2021

Proteomics goes after the muscle cell secretome!


The introduction of this great new study has all sorts of cool biology in it in terms of how skeletal muscle cells and exercise end up secreting (myokines?) that lead to all the positive things our physicians tell us they do. 

I'm most impressed with how clean and smart the experimental design is to help add new information to how a central tenant of middle school health classes actually works. Cells grown in culture are stimulated with different things and the secretome is sampled from the cultures. An HF-X is used for the LCMS and MaxQuant for the data processing. The logic of the study is really clear and well executed, and the figures clearly drive home each point the authors make. 

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