Too good to be true? We won't know until someone reproduces it, but this new method described here sounds awesome.
BTW...I'm constantly blown away by how many journals PastelBio reads / references. I've never heard of this journal -- but here is a really cool paper from it?
#1 PTM we work on -- phosphos
#2 PTM is glycos (I saw a slide deck at ASMS on that)
Why not enrich them both and just go for it. I'm sure the new Fusion tune software can recognize both neutral loss and diagnostic ions and have no trouble dealing with both in the same run! Organizing the instrument control flow chart might be a little challenging, but I'm confident it would do it!
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