Friday, October 30, 2026

"Proteins don't exist" - if you don't know the proteoform, does it even matter?


Shoutout to Jens for forwarding me this cool C&EN article I hadn't seen. We had an offer to go to iHUPO, but -wow- it was far this year for me. It's far closer in 2027 (MILAN???) and 2028 (RIO!!) which would have been scary but they exported their fascist would-be dictator to my country where we collect and empower them. 

As fast as proteomics is gaining ground in public consciousness, it's tough to miss a conference this big and especially when it looks like there were smart people stating smart things.

Do you actually care what the relative concentration of protein A is? Or do you care about how much of the active proteoform of protein A is actually there? 

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