If you've ever been here before 1) I'm sorry and 2) you probably have seen me make fun of aptamers a lot and you know I despise nanoflow chromatography. Is it a necessary evil? It is in single cell proteomics for at least a bit longer. Otherwise there are other options, like microflow or even analytical flow.
What about high flow fractionation and then direct infusion SLIM (high resolution ion mobility) + Orbitrap (high resolution mass spectrometry)? Could that work? Maybe it's worth taking a look at this new paper!
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