MASLD liver tissue AND plasma proteomics!

 

Thanks to our colleagues and affiliation with the Pittsburgh Liver Research Center we get access to a lot of human liver samples. Typically, however, this is because the liver is taken out of a person so that a new one can be put in. They don't typically take those livers out because they're in great shape. They're generally super extreme cases of bad livers. As you dig through the repositories you'll find that is often the case. Not a ton of helathy controls of livers or less terminal liver disease samples. 

Merry Xmas to me! 

Seven healthy controls WITH both liver homogenate and plasma proteomics to add to our hard drives? It is funny to me that the front page illustration shows a Sciex QQQ and the study was done with an Orbitrap Tribrid running DIA proteomics. I have one out or out soon where the other authors put an Agilent ICP-MS or something in their abstract graphic without consulting me on that change. 

All the data is up on MASSIVE here! 

What is really cool to me is that they only did the ones where they had matched plasma. Since the liver is a big organ with a tremendous interface with liquid blood stuff, the two should be closely related. And this group points out clear disparities between the two that are definitely worth my team thinking about.