Tau interactome maps and neurodegeneration!

 

Y'all, I am SO PSYCHED for US HUPO 2025. As you might know, THE Proteomics Show podcast was renewed for a 6th(Six? 6?) season! And the whole reason US HUPO put up with our antics in the first place was that we were highlighting invited speakers, award winners and the big deal plenary people.

Not to brag, but I don't really have any hobbies except reading proteomics papers and maybe finding out that there are a bunch of proteomics people together in some city (or ski resort) and going there whether I'm invited or not. As such, I'm sorta plugged into what's going on in the community. 

I personally know/knew 1 (one! yes, one!) invited speaker for US HUPO 2025. Aleksandra Nita-Lazar, who is as good of a scientist as our field has. And then - no one else. So we're legitimately interviewing completely new victims doing crazy badass science. Huge props to US HUPO for this year's line up. I need to upgrade my tablet thing because there is no way mine will survive all the notes. 

Case in point? This is just about the sickest fucking paper you could read right now and December of 2024 might be the coolest month for proteomics in all of history. I'm not joking. I can't even keep up with mindblowing advance one after another. And - again - lack of hobbies. 

How did I miss this??? I legitimately do not know.

TAU? 

APEX Interactomics??? (Temporal - hey this protein is hanging out with THESE Proteins! Right now?? Yes, right now)

Neurons generated from IPSC stem cell thingies from healthy patients and those with dementia? (Disclaimer - went to one stem cell conference in 2009, learned/absorbed very little).

So cool, and we got to spend a morning talking with Tara Tracy for the show (next weeks? week after? something soon) and I'd walk to Philly to see her speak. Google helpfully just informed me it's like 12 hours. Meh. Still would do it.