Multiplexed spatial proteomics! 50um resolution at 3,500 proteins and >120 slices/day!

 

Ying Zhu is having a solid month for his CV! 

While the resolution might not wow people in the MALDI world, the depth sure should make up for it. 3,500 proteins quantified and more than 120 "pixels" analyzed per day (a pixel is a 50um x 50um square, though it looks like they can cut smaller than this. 

With this little material and an eye on throughput - the fancy tools on the Eclipse for MS3 and Real Time Search didn't improve things.

The other interesting thing I highlighted is the batch effect correction. Original reference goes back to here (small world) with these caveats.