WOW! Did I ever blow my initial take on this paper. Not a little, but by so much that I'm a little concerned about whether I have some level of impairment in my reading and/or comprehension right now. I'm tempted to write it off as flu like symptoms while moving my family to a new city in the winter, and hoping it isn't a brain tumor, but - if you saw that post it was way off.
I'm tempted to leave my original post up here because, if there is a strength I have as a scientist, I think it is my ability to rapidly accept and own up when I'm wrong. And I was very very wrong here. However, I think given the amount of traffic this post generated, I should just link some correct information to the paper and an apology to the authors for a legitimately worrying level of inaccuracy in my interpretation of their paper.
This method doesn't just quantify your histone/histone PTMs, it also provides direct insight where those proteins currently are on the oligonucleotides. I don't know of anything with mass spectrometry that can get you anywhere near that level of insight.
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