Untargeted spatial metabolomics and proteomics with DESI and nanoPOTs!

 

I have things to do, so I'm just gonna drop this here and run, but it's super cool! 

You know those Waters DESI things that sound fantastic but no one you know has one? They're like a MALDI but things multiply charge like an ESI. Now you can get proteins and peptides and fragment things like any other ESI source - you can even use all your normal deconvolution and fragment prediction stuff in a spatial context! It looks like they don't have to matrix it, so they can do their DESI stuff, then capture off the same tissue to do proteomics. It does make me wonder if I can de-MALDI matrix but an almost 4 year old is trying to type on the same keyboard I'm using, so i should probably get going. Cool stuff, though!