This short little study is reeeeeaaaally cool, especially if you were just at an epigenetics meeting and 2 people stopped by your poster. And one was to compliment your tie (which was still appreciated!)
They have their technology for studying the epigenome and epitranscriptome. It's evolving and amazingly cool. Who cares about proteins?
Well -- this group knows what 150+ proteins do in regulating epitranscriptomic markers. So they targeted them during stem cell differentiation. And -- guess what -- the abundance of these proteins that make those modifications on nucleotides can tell you what those post-transcriptional control mechanisms are doing -- just as accurately as measuring the modified sequences themselves.
Add it together and you get an even better picture of what the cells are doing -- or what they'll be doing down the road after you stop monitoring -- which is the whole point of these epi- things! Predicting what cells and organisms will pass down to later generations outside of DNA sequence alterations.
Super cool. Short read. Good targeted quan.
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