Saturday, December 17, 2022

Derivatization of small peptides allows MALDI peptide sequencing!


The lasers have gotten better, but otherwise MALDI is sort of in the same place it has been for a long time otherwise, particularly if you're interested in peptides and proteins. 

This is a neat trick to derivatize small peptides so that they're out of that low mass range where all the junk and matrix hangs out. If the tech can't improve further, maybe what we need is smart things like this on the sample preparation side to get us past the expensive pretty picture stage! 

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