Two-thirds of proteins of the host and parasite are modified!

 

This paper is getting forwarded to a lot of people this morning!\

Experimental setup?

Red blood cells

Red blood cells + malaria (Plasmodium falciparum; the ultra-deadly on the first infection type)

Enrich for a ton of different PTMs, including: 

Phosphorylation, acetylation, crotonylation, 2- hydroxyisobutyrylation, N-glycosylation, and ubiquitination!!

Q Exactive LCMS

Stunning downsteam analysis.

INCORRECT LINK IN THE PAPER. Don't go to the WolfPSORT link in the paper! 

This is the correct link for it: https://wolfpsort.hgc.jp/ (this alone is really cool, you should check it out, it's a subcellular localization predictor)

What did they get? 

Over 2/3 of the proteins are modified! Which explains a lot of things!