Monday, November 16, 2020

Two-thirds of proteins of the host and parasite are modified!


 




Experimental setup?
Red blood cells
Red blood cells + malaria (Plasmodium falciparum; the ultra-deadly on the first infection type)
Enrich for a ton of different PTMs, including: 

Phosphorylation, acetylation, crotonylation, 2- hydroxyisobutyrylation, N-glycosylation, and ubiquitination!!
Q Exactive LCMS

Stunning downsteam analysis.

INCORRECT LINK IN THE PAPER. Don't go to the WolfPSORT link in the paper! 

This is the correct link for it: https://wolfpsort.hgc.jp/ (this alone is really cool, you should check it out, it's a subcellular localization predictor)

What did they get? 

Over 2/3 of the proteins are modified! Which explains a lot of things! 


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