One of the limitations of DIA has been "you have to know what is there first" sensitive discovery of new things? That's tough if you've got 40 bazillion ions all coisolated at once!
But what if you dropped your DIA windows to miniscule levels -- as small as what you do with DDA, and you just scanned across and fragmented all the things? Don't pass the turkey on Thursday (because turkey is gross, but not as gross as the COVID you're dumb cousin with the red hat is going to give you) PASS-DIA!
One of the things you don't have in your DIA data is a way to link your precursor up to your fragment ions. You'll need this awesome thing hosted at PNNL. It's called mPE-MMR. (Pronounced "muppet murder")