Wednesday, March 25, 2026

How do commercial procedures impact the blood plasma proteome!


Oh. This. Is. Sick.


Matt Foster and I were JUST talking about this at US HUPO. Sometimes blood gets frozen in transit, y'all. And sometimes it probably sits around on some phlebotomist's cart for a whole day and then gets frozen. 

The last paper I could find on this weird stream of consciousness website was almost 10 years old. Wait. How long have I been doing this? That seemed like a recent paper... Whatever. It was before all these fancy nanoparticle thingamabobs showed up.

Actually, I'm procrastinating - here is a rant. I'm convinced that absolutely no one understands how these nanoparticles work. For real. Y'all will give me the "protein corona" like that explains anything at all. 



That's what it said in the first Steve Carr paper and I swear they just made that term up in Boston and everyone just repeats it. Also - how do you copy a GIF on a MacBook? Why is this thing so fast and why are so many things impossible to do on it? 

Okay - but that paper! The paper takes a look at the practical real life concerns in blood plasma proteomics! Like travel time and storage time and freeze thaws! And - obviously old fashioned and new fashioned blood plasma proteomics methods. But everyone has done the latter, even if they can't agree. This one looks at the interesting stuff too! 

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