I've been hanging out with people for the last year or so who are building super high resolution ion mobility systems (at least resolution of 300 while operating, which is significantly higher than any of my TIMSTOFs). So it's funny to see benefits of taking a low resolution IMS (10?) and making it even lower!
Anything not getting trhough the FAIMS is going to waste, so this makes a lot of sense. Ultimately you're probably just using FAIMS to get rid of the +1 junk you can't sequence anyway and the PTMs that are much easier in downstream analysis to just ignore. If you can do that while losing less of your proteotypic peptides - BOOM - more signal! These authors demonstrate it adds ID#s in both standards and actual single cells!
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