Okay - so who else was limited in their thoughs of how you could apply spatial proteomics in thinking of slicing being in 2 dimensions?
This application find altered cholesterol metabolism in psoriasis patients compared to healthy matched controls at different layers of skin with the biggest differences being observed as you go down (?)
LCM used a Leica 7 and LCMS was EasyNLC 1200 on a TIMSTOF. DIA and DDA(PASEF) were used and at least some of the data was analyzed in FragPipe.
Really interesting stuff across the board.
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