Wednesday, January 3, 2024

What to get the mass spectrometrist who has everything? 200 Hz ion trap in their OrbiTOF!

 

What do you get for the mass spectrometrist who has everything? What about an ion trap inside of their OrbiTOF? 

Now - there are a lot of terms being thrown around in this great paper about a prototype of an instrument (that would probably cost more than Twitter is currently worth), which makes this seem a little less like science fiction - and a little more like...maybe I should put in that abstract for Anaheim....


Human brains are just good at detecting patterns - whether they exist or not - but if someone has already thought that "ion processor" sounds a lot better than "rectalinear collision cell inserted perpendicular in an Astral" AND drafted loads of professional schematics, it makes you wonder how far that is from production. If you are wondering if some part of the marketing department of one of the big mass spectrometry companies is on my payroll, I'm happy to say that - no - this is entirely their doing, though I'll consider it a late Xmas present! 



Anybody have any ideas for what they might do with ultra-high speed trapping and routing into an Asstral? On example shown in this study demonstrates remarkably high resolution of myoglobin at a +23 charge state -- at 200 Hz (the figure actually adverages 100 scans, so 2 Hz, but still!) 

Now....they don't spend much time on it in the paper, but.....this prototype system clearly exceeds 100,000 resolution following ion processor fragmentation (!!!!!!!!!!!!!)

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