One nasty little secret in LCMS is that we're only getting about 1% of the molecules from the liquid phase into the charged gas phase. We can do all sorts of great things inside the instruments (and have) to improve the efficiency of those gas phase ions, but even at 100% efficiency internally (which we don't have, I don't care what anyone says, and you shouldn't either) there are big dividends on the outside.
Check out the ridiculous numbers this little front end ion transfer tube alteration picks up!
It reminds me of something, I can't think of what, but if these numbers are real (those are log intensity values in C!) I think it's time to visit the machining shop down the street!
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