This is a really interesting study describing the progress toward finding the "missing" human proteins (the ones that genomics says should be there, but we haven't been able to find protein data for).
--and reanalyzing a few (1,000!) of the files toward just one chromosome of the Chromosomal Centric Human Proteome Project (C-HPP).
An interesting take-away for me from this study is that it appears that we are approaching a state of diminishing returns due to how much effort goes into the identification of so few peptides. We've found the easy ones, I guess! Time to think up some new strategies?