I'm just going to leave this here. It's from this study from Andrew Krutchinksy et al. a couple of years ago.
It appears (to this biologist) to be a relatively minor alteration to the front of an instrument that causes an impressive gain in the efficiency of ion transmission from ionization to detection.
The authors conclude with some really interesting assays that the mechanism of action is probably something like this.
A mixture of light and heavy peptides looks pretty convincing (to this biologist).
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