At ASMS 2017 in scenic Indianapolis, a new functionality called Advanced Precursor Determination was rolled out for the Q Exactive HF-X and Fusion Lumos systems from TFS.
Details were a little vague on how this worked, but this new Just Accepted study at JPR fills in all the blanks!
Maybe details were a little scarce because you need a flow chart to explain how it works?
There is a lot of other good stuff in this study including some up-to-date numbers on theoretical cycle time required to select all peptides for fragmentation in a complex mixture as well as a good explanation why we don't always hit our TopN.
Highly recommended, even just for better understanding sampling dynamics!
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