Sunday, December 31, 2017

Functional proteolytic cleavage proteoforms as PTMs?


Ouch...okay....this review is seriously dense and worth taking a look at if only to think about how much potential biology we may be missing because we cut all our proteins up with enzymes and lose much, if not all of the information this review is focused on....

It is no surprise their for shortened protein variants out there. My problem conceptually here is the number of them that are stable and functional and the number of mechanisms that they are derived from. Maybe I just need more coffee, but this bears a much closer look! Especially as you see how critical these cleavage variants appear to be to central canonical pathways. Considering how few pathways are known compared to the unknown ones makes this matrix seem more than a little daunting.

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