NA-NA-NA-NA-NA-NA-NA-NA-BATMASS!!!! So glad this is out so I can finally talk about this!
Okay. SOOOOO...Orbitrap data is BIG DATA. For real. Unfortunately, we've been looking at it in such a limited way that we really haven't realized it yet. Don't worry, I'm going to ramble on and on about this as time permits.
[Dedacted rambling about other cool things I can't talk about yet!!! Shut up Ben, shut up. You can see the ENTIRE PROTEOME ITS ALL THER..QUIT TYPING!!! Dedacted]
How do other fields deal with Big Data? P.S. this book is somewhat off topic, but awesome. You've got to step away from the small ways of dealing with things and look at the big picture. Its hard to do. Let go. And look for trends.
Enter BatMass. Batmass takes us away from looking at individual MS scans and away from searching against limited and often incorrect databases and sums your RAW files up into a picture. A zoomable, scalable, searchable, overlayable picture!
Check out this fuzzy example. Step away from these 9 RAW files and --- BOOM! (One of these things is not like the others!)
Rapidly, visually locate what is different --- you can use it to find files where something went awry -- or to look for your differentially expressed molecules between files. Once you find them, you have an entire tool suite to
Zoom in and extract the data of interest. Seriously! I love this concept (if you can't tell)... Better yet, its experiment-independent. BatMass doesn't care if this is a proteomics experiment or a metabolomics run or an untargeted food screening run - it just does its job and visualizes the differences it sees (this corn syrup has a pesticide we didn't even think to look for -- what?! Your drug changes the global lysine acetylome -- what?!?)
If you just want to get it and mess around with it -- its Batmass.org
You'll find a nice getting started guide for mass spec people and some overview videos. You'll also find resources (and the original source code) for developers who want to take this concept further or integrate it into their workflows!!