Did I know what a gastruloid was before yesterday? Related, do you have gastroids?
Here is a link and there are reasons this ultracool study is making the popsci popups!
This is one of the earliest stages of mammalian development - studied at ridiculously high depth here by RNA-Seq, proteomics (by TMT SPS RT MS3) and phosphoproteomics by the same.
Don't feel like reading? Check out this awesome interactive webpage with protein networks and protein by protein visual analysis.
Edit: I thought it had phosphopeptide interactions mapped, but I think I just clicked on a bunch of phosphoproteins coincidentally. I also implied that protein-protein interactions were performed in the study, but when I got to the methods I realized that this was a complex and multi-level meta-analysis. It's easier for me to copy pasta here. There is a Github up for reproducing this analysis as well.
Solid and very interesting work, even if RTS was employed. 😇
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