RIPUP histones to rapidly find a new pile of post-translational modifications!

 

This new preprint is so legit. Not only does it identify a pile of histone post-translational modifications I didn't know about, but it does it fast AND it justifies the chemistry that makes it happen. 

What if the reason that some of these PTMs aren't visible is that the modification neutralizes that peptide's ability to pick up a charge? Makes sense. A lot of the more awful PTMs do. 

But what if you could make them visible by adding a boring ol' tandem mass tag? Bonus points for the introduction of an enzyme I didn't know about with an amazing name:

Stop, don't read this. Next line until someone is around and then read it really loud! 

"HEY! Someone order me some ULTRA ARRRRRRGGGG-C!!!!!"