Poor RNA to protein correlations are an artifact of poor proteomics data?

 

I was making slides for a class lecture and went down a long and windy rabbit hole on what we now know about the discrepancies between RNA and protein regulation. I landed on this one from 2022, and while it may seem like I'm rage baiting....I think it should go here anyway..

Despite the title of this blog post we aren't firmly blamed for all the errors. Some error does exist in the mRNA measurements, but it's pretty clear that the disagreement in protein measurements between different studies is something that is worth thinking about.