You'd think it would be easy to find something written in the last couple of years that was about tissue-specific proteomics, right?
You would be very very very wrong. I have 9 tabs open on just the PC I'm standing in front of in my house (wait. why am I here? I have a meeting in Oakland in like 30 minutes...? TYPE FAST!)
In 8 of these papers, the authors who wrote it used the GTEX RNA DATA to determine organ specificity. As you might remember from some of my earlier rantings, GTEX prediction of proteins in organs is better than flipping a coin. Just not by a lot.
This extremely polite group integrated the GTEX data, but went ahead and did organ specific proteomics (in-gel digestion 6 cut QE HF / QE HF-X) on their own. (Sorry, really truly moving fast, I can't reference the methods.) Then they were extremely polite and constructive and integrate the GTEX findings into their analysis. They go with something like "if 2 out of 3 atlases show a protein is organ specific" then they consider it specific and move on. I don't know the origin of the second (probably RNA atlas) but that's one reason I was super annoyed I misplaced this paper! Now I won't!
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